Ciproking 500

Description

💊 Ciproking – Ciprofloxacin 500 mg

Manufacturer: SinoHealth Pharmaceuticals LTD

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1. Presentation:

• Oral Dosage Form: 500 mg tablets

• Extended-release Tablets: 500 mg once or twice daily as required

• Injectable Dosage Form: IV infusion

• Strength: 500 mg per tablet

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2. Description / Pharmacology:

Ciproking contains Ciprofloxacin, a synthetic quinolone antibacterial agent with broad-spectrum activity.

• Active against most Gram-negative aerobic bacteria, including Enterobacteriaceae and Pseudomonas aeruginosa.

• Effective against certain Gram-positive aerobic bacteria, including penicillinase-producing and methicillin-resistant staphylococci.

• Bactericidal action results from interference with DNA gyrase, required for bacterial DNA synthesis.

• Rapidly and well absorbed orally; widely distributed into body tissues and fluids.

• Half-life: ~3.5 hours; 30–50% excreted in urine within 24 hours as unchanged drug or active metabolites.

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3. Indications:

Ciproking 500 mg is indicated for:

• Single or mixed infections caused by susceptible organisms

• Infections resistant to other antibiotics (Aminoglycosides, Penicillins, Cephalosporins)

• Urinary tract infections, respiratory tract infections, gonorrhea, skin and soft tissue infections, bone and joint infections, intra-abdominal infections, sinusitis, chronic bacterial prostatitis

Use only under the supervision of a registered physician.

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4. Dosage & Administration:

Oral Tablets (500 mg standard):

• Adults: 500 mg twice daily, depending on infection type and severity

• Urinary tract infections: 500 mg twice daily

• Respiratory infections: 500 mg twice daily; adjust as needed for Streptococcus pneumoniae

• Gonorrhea: Single dose 500 mg

• Other infections: 500 mg twice daily

• Cystic fibrosis with Pseudomonas: 500 mg twice daily

Extended-release Tablets:

• Uncomplicated urinary tract infection: 500 mg once daily for 3 days

IV Infusion:

• Administered according to infection type, severity, and patient characteristics (follow standard 500 mg IV regimens)

• Check IV bags for leaks, cloudiness, or precipitates; follow standard infusion protocol

Special Populations:

• Elderly: No dosage adjustment generally needed

• Impaired renal function: Reduce total daily dose by half if serum creatinine >265 μmol/L or creatinine clearance <20 mL/min

• Children & Adolescents: Generally not recommended due to potential arthropathy

Continue treatment 3 days after resolution of symptoms unless otherwise directed.

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5. Interaction:

• Avoid concurrent administration with magnesium or aluminum-containing antacids, sucralfate, calcium, iron, or zinc supplements (take 2 hours after or 6 hours before Ciproking)

• Avoid concurrent intake with milk or yogurt alone; dietary calcium as part of a meal has minimal effect

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6. Contraindications:

• Hypersensitivity to Ciprofloxacin or other quinolones

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7. Side Effects:

• Gastrointestinal: nausea, diarrhea, vomiting, dyspepsia, abdominal pain

• CNS: headache, dizziness, fatigue, confusion, seizures, risk of retinal detachment

• Hypersensitivity: skin rash, pruritus, rarely Stevens-Johnson syndrome or toxic epidermal necrolysis

• Other: joint pain, mild photosensitivity, transient liver enzyme elevation, serum bilirubin, urea, creatinine changes

• Rare: hypoglycemia, mental health effects

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8. Pregnancy & Lactation:

• Animal studies show no teratogenicity, but use in pregnancy not recommended due to risk of arthropathy

• Excreted in milk; avoid during breastfeeding

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9. Precautions & Warnings:

• Use with caution in patients with CNS disorders, arteriosclerosis, or epilepsy

• Encourage liberal fluid intake during therapy

• Avoid interactions with antacids, sucralfate, and mineral supplements

• Can be taken with or without meals (except dairy alone)

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10. Overdose Effects:

• Symptoms: seizures, hallucinations, confusion, abdominal discomfort, renal and hepatic impairment, crystalluria, hematuria, reversible renal toxicity

• Supportive treatment recommended

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11. Therapeutic Class:

• 4-Quinolone antibacterial, Anti-diarrhoeal antimicrobial

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12. Storage Conditions:

• Store below 30°C, protected from light and moisture

• Keep out of reach of children