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Coralpro DX

Coral Calcium + Vitamin D3
500mg + 200
SinoHealth Pharmaceuticals LTD

Description

💊 Coralpro DX – Calcium + Vitamin D3 Tablet

Manufacturer: SinoHealth Pharmaceuticals LTD

1. Indications:

Coralpro DX is indicated for:

  • Prevention and treatment of calcium and vitamin D3 deficiency

  • Support of bone health and osteoporosis management

  • Supplementation during pregnancy and lactation in case of deficiency

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2. Pharmacology:

  • Calcium is an essential mineral for bone, teeth, muscle, and nerve function.

  • Vitamin D3 (cholecalciferol) enhances calcium absorption in the gastrointestinal tract.

  • Combined therapy ensures adequate serum calcium levels and supports bone mineralization.

3. Interaction:

  • Thiazide diuretics: Reduce urinary calcium excretion; monitor serum calcium.

  • Systemic corticosteroids: Reduce calcium absorption; dose adjustment may be needed.

  • Cholestyramine or paraffin oil: May reduce vitamin D absorption.

  • Tetracyclines: Should be administered 2 hours before or 4–6 hours after calcium intake.

  • Cardiac glycosides: Hypercalcaemia may increase toxicity; monitor ECG and serum calcium.

  • Bisphosphonates / sodium fluoride: Administer Coralpro DX at least 3 hours before these drugs.

  • Foods high in oxalic acid (spinach, rhubarb) and phytic acid (whole cereals): May inhibit calcium absorption; avoid intake within 2 hours of the tablet.

4. Contraindications:

  • Hypercalcemia and hyperparathyroidism

  • Hypercalciuria and nephrolithiasis

  • Hypersensitivity to any component of the preparation

  • Severe renal insufficiency

  • Concomitant digoxin therapy (requires careful serum calcium monitoring)

5. Side Effects:

  • Gastrointestinal irritation and constipation

  • Hypercalcemia (rare, usually in renal failure or high doses)

  • Allergic reactions, irregular heartbeats, nausea, vomiting, decreased appetite, dry mouth, drowsiness

  • Skin rash reported following vitamin D administration

6. Pregnancy & Lactation:

  • Daily intake should not exceed 1500 mg calcium and 600 IU vitamin D3.

  • Avoid overdoses; high doses may affect fetal development.

  • Can be used if calcium or vitamin D deficiency is present.

  • Calcium and vitamin D3 pass into breast milk; consider this during supplementation.

7. Precautions & Warnings:

  • Monitor serum calcium and renal function during long-term use.

  • Special care for elderly, patients on cardiac glycosides or diuretics, or with high tendency for kidney stones.

  • Dose adjustment or discontinuation in case of hypercalcaemia or impaired renal function.

  • Use caution in patients with sarcoidosis or immobilized patients with osteoporosis.

  • Monitor calcium and phosphate levels when prescribing other vitamin D-containing drugs.

8. Overdose Effects:

  • Hypervitaminosis D and hypercalcaemia

  • Symptoms: anorexia, thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, mental disturbances, polyuria, polydipsia, bone pain, nephrocalcinosis, nephrolithiasis, cardiac arrhythmias

  • Severe cases: coma, death, irreversible renal damage, soft tissue calcification

  • Management: Discontinue calcium, thiazide diuretics, lithium, vitamin A, cardiac glycosides; gastric emptying if necessary; rehydration; supportive therapy with loop diuretics, bisphosphonates, calcitonin, corticosteroids; monitor serum electrolytes, renal function, ECG, and CVP

9. Therapeutic Class:

Specific mineral & vitamin combined preparations

10. Storage Conditions:

  • Store below 30°C, protected from light and moisture

  • Keep out of the reach of children

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