Dexlanpro

Description

💊 Product Name: Dexlanpro – Dexlansoprazole

Manufacturer: SinoHealth Pharmaceuticals LTD

---

Indications

✅ Healing of Erosive Esophagitis: For healing of all grades of erosive esophagitis (EE) for up to 8 weeks.
✅ Maintenance of Healed Erosive Esophagitis: To maintain healing of EE and relief of heartburn for up to 6 months.
✅ Symptomatic Non-Erosive GERD: For the treatment of heartburn associated with symptomatic non-erosive Gastroesophageal Reflux Disease (GERD) for 4 weeks.

🩺 রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

---

Pharmacology

Dexlansoprazole is a Proton Pump Inhibitor (PPI) that suppresses gastric acid secretion by specifically inhibiting the (H+/K+)-ATPase enzyme in the gastric parietal cell.
It is the R-enantiomer of lansoprazole and is formulated as a Dual Delayed Release (DDR) capsule containing two types of enteric-coated granules with different pH-dependent dissolution profiles.
This dual release system produces two plasma peaks — one within 1–2 hours and another within 4–5 hours, ensuring prolonged acid suppression.
Dexlansoprazole is extensively metabolized in the liver and excreted mainly through urine.

---

Dosage & Administration

💧 Healing of Erosive Esophagitis: 60 mg once daily for up to 8 weeks.
💧 Maintenance of Healed EE & Relief of Heartburn: 30 mg once daily (up to 6 months).
💧 Symptomatic Non-Erosive GERD: 30 mg once daily for 4 weeks.

Administration:

• Can be taken with or without food.

• Swallow the capsule whole.

• Alternatively, open capsule and sprinkle granules on one tablespoon of applesauce — swallow immediately without chewing.

• If a dose is missed, take as soon as possible. Do not double the dose.

🩺 রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

---

Interactions

⚠️ With medicines: Atazanavir, Warfarin, Tacrolimus, Clopidogrel, Methotrexate.
⚠️ With food & others: No clinically significant data available.

---

Contraindications

❌ Known hypersensitivity to Dexlansoprazole or any component of the formulation.

---

Side Effects

Common side effects may include:

• Diarrhea

• Abdominal pain

• Nausea

• Vomiting

• Flatulence

---

Pregnancy & Lactation

• Pregnancy Category B: No adequate or well-controlled studies in pregnant women.

• Lactation: Safety not established; use only if clearly needed.

---

Precautions & Warnings

⚠️ Use with caution in patients with:

• Gastric malignancy suspicion

• Clostridium difficile–associated diarrhea

• Bone fractures

• Hypomagnesemia

• Concomitant use with Methotrexate

---

Use in Special Populations

👶 Children (<12 years): Safety not established.
👴 Geriatric use: No dose adjustment required.
💧 Renal impairment: No dose adjustment necessary.
🫀 Hepatic impairment: For moderate hepatic impairment, maximum 30 mg/day is recommended.

---

Overdose Effects

No significant overdose cases reported.
Multiple doses up to 120 mg and single doses of 300 mg were well tolerated.

---

Therapeutic Class

Proton Pump Inhibitor (PPI)

---

Storage Conditions

• Store below 30°C in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.