Livofloxin 500

Description

💊 Livofloxin 500 – Levofloxacin 500

Manufacturer: SinoHealth Pharmaceuticals LTD

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1. Presentation:

• Tablet: 250 mg / 500 mg / 750 mg

• Oral Solution: [Specify if available]

• Injection: 250 mg / 500 mg / 750 mg for IV infusion

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2. Description / Pharmacology:

Levofloxacin is a synthetic, broad-spectrum, third-generation fluoroquinolone antibiotic. It inhibits bacterial topoisomerase IV and DNA gyrase, enzymes essential for DNA replication, transcription, repair, and recombination.

Pharmacological actions:

• Bactericidal against a wide range of Gram-positive and Gram-negative microorganisms

• Effective in treating infections of respiratory tract, urinary tract, skin, soft tissues, and enteric infections

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3. Indications:

Livofloxin 500 is indicated for treatment of infections caused by susceptible bacteria:

• Acute maxillary sinusitis

• Acute bacterial exacerbation of chronic bronchitis

• Community-acquired pneumonia

• Uncomplicated & complicated urinary tract infections

• Acute pyelonephritis

• Uncomplicated & complicated skin and soft tissue infections

• Enteric infections (e.g., typhoid, cholera, shigellosis)

রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

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4. Dosage & Administration:

Oral administration:

• Adults:

  • Acute sinusitis: 500 mg once daily for 10–14 days or 750 mg once daily for 5 days

  • Chronic bronchitis exacerbation: 500 mg once daily for 7 days or 750 mg once daily (3–5 days depending on severity)

  • Community-acquired pneumonia: 500 mg once daily for 7–14 days or 750 mg once daily for 5 days

  • Uncomplicated UTI: 250 mg once daily for 3 days

  • Complicated UTI & acute pyelonephritis: 250 mg once daily for 7–10 days

  • Skin/soft tissue infections: 500–750 mg once daily depending on severity

  • Enteric fever: 500 mg once daily for 7–14 days

  • Diarrhea, cholera, shigellosis: 500 mg once daily, mild-to-moderate; 500 mg daily for 3 days, moderate-to-severe

• Children:

  • 6 months to <5 years: 10 mg/kg every 12 hours

  • 5 years: 10 mg/kg every 24 hours

IV administration (Infusion):

• Administered slowly over 60–90 minutes depending on dose

• Adults: 250–500 mg every 24 hours; 750 mg over 90 minutes every 24 hours if indicated

• Sequential therapy (IV → Oral) may be instituted at physician’s discretion

রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

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5. Drug Interactions:

• Antacids, iron, or adsorbents: Reduce absorption

• NSAIDs: May increase CNS stimulation risk

• Warfarin: May increase bleeding risk

• Multivalent cations (Mg, Ca, Al): Avoid co-administration through same IV line

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6. Contraindications:

• Hypersensitivity to levofloxacin, quinolones, or any component of the formulation

• Children under 16 years

• Prophylactic use before surgery

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7. Side Effects:

• Common: Nausea, vomiting, diarrhea, abdominal pain, flatulence, mild phototoxicity (0.1%)

• Rare: Tremors, depression, anxiety, confusion, retinal detachment

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8. Pregnancy & Lactation:

• Not recommended during pregnancy or lactation

• Effects on fetus or nursing infant are unknown

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9. Precautions & Warnings:

• Administer IV infusion slowly (60–90 min)

• Ensure adequate hydration

• Dose adjustment in renal insufficiency

• Monitor for CNS side effects when combined with NSAIDs

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10. Overdose Effects:

• Low acute toxicity

• Gastric emptying and supportive care recommended

• Maintain hydration and monitor patient

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11. Therapeutic Class:

• 4-Quinolone antibiotics

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12. Storage Conditions:

• Store below 30°C, away from light and moisture

• Keep out of reach of children