Torento 90

Description

💊 Terento 90 – Etoricoxib 90 mg Tablet

Manufacturer: SinoHealth Pharmaceuticals LTD

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1. Indications:

Torento 90 is indicated for the symptomatic relief of:

• Osteoarthritis (OA)

• Rheumatoid Arthritis (RA)

• Ankylosing Spondylitis

• Pain and inflammation associated with acute gouty arthritis

• Short-term treatment of moderate pain after dental surgery

রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

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2. Pharmacology:

Etoricoxib is a potent, orally active, COX-2 selective inhibitor.

There are two forms of cyclooxygenase:

• COX-1: Responsible for normal physiological functions such as gastric protection and platelet aggregation.

• COX-2: Mainly responsible for the synthesis of prostaglandins that cause pain, inflammation, and fever.

By selectively inhibiting COX-2, Etoricoxib relieves pain and inflammation without affecting COX-1, reducing the risk of gastric damage and bleeding.
At doses up to 90 mg daily, Etoricoxib inhibits COX-2 without inhibiting gastric prostaglandin synthesis.

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3. Dosage & Administration:

Adults and adolescents (16 years and older):

• Osteoarthritis: 30 mg once daily (may increase to 60 mg if needed).

• Rheumatoid Arthritis: 90 mg once daily.

• Ankylosing Spondylitis: 90 mg once daily.

• Acute Gouty Arthritis: 90 mg once daily (short-term as per physician).

• Postoperative Dental Pain: 90 mg once daily (up to 3 days).

⚠️ Use the lowest effective dose for the shortest possible duration.
Reassess the patient’s need for continued therapy periodically.

রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

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4. Drug Interactions:

With Medicines:

• Warfarin: May increase prothrombin time.

• Diuretics, ACE inhibitors, Angiotensin II antagonists: May reduce antihypertensive effects.

• Low-dose Aspirin: Can be used together for cardiovascular prophylaxis.

• Ciclosporin or Tacrolimus: May increase nephrotoxicity risk.

• Lithium: May increase lithium levels by reducing renal excretion.

With Food:

• Can be taken with or without food.

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5. Contraindications:

• Hypersensitivity to Etoricoxib or any excipients

• Active peptic ulcer or gastrointestinal bleeding

• History of asthma, urticaria, or allergic reactions to NSAIDs or aspirin

• Pregnancy and lactation

• Severe hepatic impairment (Child-Pugh ≥10 or serum albumin <25 g/L)

• Renal impairment (CrCl <30 mL/min)

• Children under 16 years

• Inflammatory bowel disease

• Congestive heart failure (NYHA II–IV)

• Uncontrolled hypertension (≥140/90 mmHg)

• Established ischemic heart disease, peripheral arterial disease, or cerebrovascular disease

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6. Side Effects:

• Common: Palpitation, fatigue, influenza-like symptoms, dizziness

• Less common: Dry mouth, taste disturbance, appetite change, atrial fibrillation, cough, dyspnoea, anxiety

• Rare: Confusion, hallucinations, weight change, mouth ulcer, paraesthesia, muscle/joint pain

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7. Pregnancy & Lactation:

• Not recommended for women attempting to conceive.

• Contraindicated during pregnancy and lactation.

• Excreted in rat milk; human excretion unknown.

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8. Precautions & Warnings:

• Use cautiously in elderly patients and those with a history of ulcers or GI bleeding.

• Monitor patients with cardiovascular risk factors (hypertension, diabetes, smoking).

• Monitor renal function in patients with dehydration, renal impairment, or heart failure.

• Discontinue if liver dysfunction or abnormal LFTs occur.

• Stop treatment if skin rash or hypersensitivity appears.

• May mask fever or signs of infection.

• Caution when co-administered with warfarin or anticoagulants.

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9. Overdose Effects:

• Single doses up to 500 mg or multiple doses up to 150 mg/day show no major toxicity.

• In overdose: apply supportive measures — gastric lavage, monitoring, and symptomatic care.

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10. Therapeutic Class:

Non-Steroidal Anti-Inflammatory Drug (NSAID) – COX-2 Selective Inhibitor

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11. Storage Conditions:

• Store below 30°C, protected from light and moisture.

• Keep all medicines out of the reach of children.